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Neurochemistry Research Group

Division of Neurosurgery

Studying at Cambridge

 

Clinical trials

Our microdialysate analysis contributes to clinical trials, demonstrating penetration of drugs across the blood-brain barrier and effects on downstream targets.  Our study (MRC funded) on human recombinant IL-1ra in TBI patients has been published by Helmy et al., 2015. We have recently analysed patient samples in a sub-study (NIHR funded) of the CRASH-3 trial of tranexamic acid in TBI patients. In addition to our analysis of microdialysis samples, we also perform studies on other matrices including CSF, plasma and more recently, subdural fluid. We have also completed biochemical studies to support the work being done on a large multi-centre trial (Dex-CSDH) of dexamethasone for patients with chronic subdural haematoma. The lab studies will enable us to identify biomarkers associated with the pathogenesis of chronic subdural haematomas and how dexamethasone can be used to target these and promote recovery from this condition.