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Neurochemistry Research Group

Division of Neurosurgery

Recent Publications:


'Monitoring Neurochemistry in Traumatic Brain Injury Patients Using Microdialysis Integrated with Biosensors: A Review'
Zimphango C, Alimagham FC, Carpenter KLH, Hutchinson PJ, Hutter T
Metabolites 2022. 12(5):393. Full article available here.

'Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.
Abdelhakim Khellaf*, Nuria Marco Garcia*, Tamara Tajsic, Aftab Alam, Matthew G Stovell, Monica J Killen, Duncan J Howe, Mathew R Guilfoyle, Ibrahim Jalloh, Ivan Timofeev, Michael P Murphy, T Adrian Carpenter, David K Menon, Ari Ercole, Peter J Hutchinson, Keri LH Carpenter†, Eric P Thelin†, Adel Helmy†
Journal of Cerebral Blood Flow & Metabolism 2022. 42(1):39-55. doi: 10.1177/0271678X211042112. Full article available here.


'Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients.'
Guilfoyle MR, Helmy A, Donnelly J, Joseph Donnelly, Matthew G. Stovell,Ivan Timofeev, John D. Pickard, Marek Czosnyka, Peter Smielewski, David K. Menon, Keri L. H. Carpenter, Peter J. Hutchinson
PLOS ONE 2021 16(12): e0260291. doi: 10.1371/journal.pone.0260291 Full article available here.

'Research Evaluating Sports ConcUssion Events—Rapid Assessment of Concussion and Evidence for Return (RESCUE-RACER): a two-year longitudinal observational study of concussion in motorsport'
Deakin ND, Suckling J, Hutchinson PJ
BMJ Open Sport & Exercise Medicine 2021 ;7:e000879. doi: 10.1136/bmjsem-2020-000879 Full article available here.

'Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury'
Lassarén P, Lindblad C, Frostell A, Carpenter KLH, Guilfoyle MR, Hutchinson PJA, Helmy A, Thelin EP.
J Neuroinflammation. 2021 25;18(1):221. doi: 10.1186/s12974-021-02264-2. Full article available here.

'Cerebral Microdialysate Metabolite Monitoring using Mid-infrared Spectroscopy'
Farah C. Alimagham, Dan Hutter, Núria Marco-García, Emma Gould, Victoria H. Highland, Anna Huefner, Susan Giorgi-Coll, Monica J. Killen, Agnieszka P. Zakrzewska, Stephen R. Elliott, Keri L. H. Carpenter, Peter J. Hutchinson, and Tanya Hutter
Analytical Chemistry 2021 .DOI: 10.1021/acs.analchem.1c01149. Full article available here.


'Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma.
Thelin EP, Hall CE, Tyzack GE, Frostell A, Giorgi-Coll S, Alam A, Carpenter KLH, Mitchell J, Tajsic T, Hutchinson PJ, Patani R, Helmy A. J Neurotrauma. 2020 Jan 1;37(1):93-105. doi: 10.1089/neu.2019.6480. Epub 2020 Sep 18. PMID: 31452443 Full article available here.

'Dextran 500 Improves Recovery of Inflammatory Markers: An In VitroMicrodialysis Study.
Giorgi-Coll S, Thelin EP, Lindblad C, Tajsic T, Carpenter KLH, Hutchinson PJA, Helmy A. J Neurotrauma. 2020 Jan 1;37(1):106-114. doi: 10.1089/neu.2019.6513. Epub 2019 Aug 6. PMID: 31298609 Full article available here.

'Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI.
Stovell MG, Mada MO, Carpenter TA, Yan JL, Guilfoyle MR, Jalloh I, Welsh KE, Helmy A, Howe DJ, Grice P, Mason A, Giorgi-Coll S, Gallagher CN, Murphy MP, Menon DK, Hutchinson PJ, Carpenter KL. J Cereb Blood Flow Metab. 2020 Jan;40(1):67-84. doi: 10.1177/0271678X18799176. Epub 2018 Sep 18. PMID: 30226401 Full article available here.


'Metabolism and inflammation: implications for traumatic brain injury therapeutics'
Monica J Killen, Susan Giorgi-Coll, Adel Helmy, Peter JA Hutchinson & Keri LH Carpenter. 
Expert Review of Neurotherapeutics, 19:3, 227-2422019. 10.1080/14737175.2019.1582332. Full article available here.

'Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase'
Ellie Edlmann, Eric P. Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z. Al- Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G Kolias, Peter J. A. Hutchinson & Dex-CSDH Trial Collaborative And BNTRC Collaborative. 
Scientific Reports, 2019. 10.1038/s41598-019-42087-z. Full article available here.

'Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial (vol 19, 670, 2018)'
Angelos G. Kolias†, Ellie Edlmann†, Eric P. Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner,Kevin Owusu-Agyemang, Yahia Z. Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner,Lynne Whitehead, Ian Wilkinson, Peter J. Hutchinson and British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators. †Joint first Authors. 
Trials, 2019. 10.1186/s13063-019-3283-x. Full article available here.



'The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury'
Stovell, Matt & Mada, Marius & Helmy, Adel & Carpenter, Thomas & Thelin, Eric & Yan, Jiun-Lin & R. Guilfoyle, Mathew & Jalloh, Ibrahim & Howe, Duncan & Grice, Peter & Mason, Andrew & Giorgi-Coll, Susan & N. Gallagher, Clare & P. Murphy, Michael & Menon, David & J. Hutchinson, Peter & L. H. Carpenter, Keri.
Scientific Reports, 2018. 10.1038/s41598-018-29255-3. Full article available here.

'A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain'
Jalloh, Ibrahim & Helmy, Adel & Howe, Duncan & Shannon, Richard & Grice, Peter & Mason, Andrew & N. Gallagher, Clare & P Murphy, Michael & Pickard, John & K Menon, David & Adrian Carpenter, Thomas & John Hutchinson, Peter & L H Carpenter, Keri. 
Journal of Neurotrauma, 2018. 10.1089/neu.2017.5459. Full article available here.

'Elucidating Pro-inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model'
Eric Peter Thelin, Claire E. Hall, Kunal Gupta, Keri L.H. Carpenter, Siddharthan Chandran, Peter J. Hutchinson, Rickie Patani, and Adel Helmy. 
Journal of Neurotrauma, 2018. 10.1089/neu.2017.5155. Full article available here.



'Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction'
by Susan Giorgi-Coll, Ana I Amaral, Peter JA Hutchinson, Mark R Kotter and Keri L.H. Carpenter.
Scientific Reports, 2017. Full article available here.

'Assessing Metabolism and Injury in Acute Human Traumatic Brain Injury with Magnetic Resonance Spectroscopy: Current and Future Applications'
Stovell, Matt & Yan, Jiun-Lin & Sleigh, Alison & Mada, Marius & Carpenter, Thomas & J. A. Hutchinson, Peter & L. H. Carpenter, Keri. 
Frontiers in Neurology, 2017. 10.3389/fneur.2017.00426. Full article available here.

'Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy'
by Ellie Edlmann, Susan Giorgi-Coll, Peter C Whitfield, Keri LH Carpenter and Peter J Hutchinson.
Journal of Neuroinflammation, 2017. Full article available here.

'Heparin-gold nanoparticles for enhanced microdialysis sampling'
Giorgi-Coll, Susan, Blunt-Foley, Holly, J. A. Hutchinson, Peter & L. H. Carpenter, Keri. 
Analytical and Bioanalytical Chemistry 2017. 10.1007/s00216-017-0447-y. Full article available here.

'Microdialysis monitoring in clinical traumatic brain injury and its role in neuroprotective drug development'
by Eric P Thelin, Keri LH Carpenter, Peter J Hutchinson and Adel Helmy.
The AAPS Journal, 2017. Full article available here.


'Focally perfused succinate potentiates brain metabolism in head injury patients'
by Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson and Keri LH Carpenter.
Journal of Cerebral Blood Flow and Metabolism, 2016. Full article available here.

'Extracellular N-Acetylaspartate in Human Traumatic Brain Injury'
by Richard Shannon, Susan van der Heide, Eleanor L. Carter, Ibrahim Jalloh, David K. Menon, Peter J. Hutchinson, and Keri L.H. Carpenter. 
Journal of Neurotrauma, 2016. Full article available here.


Publications 2010-2016


Updates: 12/05/2021
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Updates: 14/10/2021
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