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Neurochemistry Research Group

Division of Neurosurgery

Studying at Cambridge


Recent Publications

Recent Publications:

'Metabolism and inflammation: implications for traumatic brain injury therapeutics'
Monica J Killen, Susan Giorgi-Coll, Adel Helmy, Peter JA Hutchinson & Keri LH Carpenter. 
Expert Review of Neurotherapeutics, 19:3, 227-2422019. 10.1080/14737175.2019.1582332. Full article available here.

'Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase'
Ellie Edlmann, Eric P. Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z. Al- Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G Kolias, Peter J. A. Hutchinson & Dex-CSDH Trial Collaborative And BNTRC Collaborative. 
Scientific Reports, 2019. 10.1038/s41598-019-42087-z. Full article available here.

'Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial (vol 19, 670, 2018)'
Angelos G. Kolias†, Ellie Edlmann†, Eric P. Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner,Kevin Owusu-Agyemang, Yahia Z. Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A. Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J. Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner,Lynne Whitehead, Ian Wilkinson, Peter J. Hutchinson and British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators. †Joint first Authors. 
Trials, 2019. 10.1186/s13063-019-3283-x. Full article available here.



'The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury'
Stovell, Matt & Mada, Marius & Helmy, Adel & Carpenter, Thomas & Thelin, Eric & Yan, Jiun-Lin & R. Guilfoyle, Mathew & Jalloh, Ibrahim & Howe, Duncan & Grice, Peter & Mason, Andrew & Giorgi-Coll, Susan & N. Gallagher, Clare & P. Murphy, Michael & Menon, David & J. Hutchinson, Peter & L. H. Carpenter, Keri.
Scientific Reports, 2018. 10.1038/s41598-018-29255-3. Full article available here.

'A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain'
Jalloh, Ibrahim & Helmy, Adel & Howe, Duncan & Shannon, Richard & Grice, Peter & Mason, Andrew & N. Gallagher, Clare & P Murphy, Michael & Pickard, John & K Menon, David & Adrian Carpenter, Thomas & John Hutchinson, Peter & L H Carpenter, Keri. 
Journal of Neurotrauma, 2018. 10.1089/neu.2017.5459. Full article available here.

'Elucidating Pro-inflammatory Cytokine Responses after Traumatic Brain Injury in a Human Stem Cell Model'
Eric Peter Thelin, Claire E. Hall, Kunal Gupta, Keri L.H. Carpenter, Siddharthan Chandran, Peter J. Hutchinson, Rickie Patani, and Adel Helmy. 
Journal of Neurotrauma, 2018. 10.1089/neu.2017.5155. Full article available here.



'Succinate supplementation improves metabolic performance of mixed glial cell cultures with mitochondrial dysfunction'
by Susan Giorgi-Coll, Ana I Amaral, Peter JA Hutchinson, Mark R Kotter and Keri L.H. Carpenter.
Scientific Reports, 2017. Full article available here.

'Assessing Metabolism and Injury in Acute Human Traumatic Brain Injury with Magnetic Resonance Spectroscopy: Current and Future Applications'
Stovell, Matt & Yan, Jiun-Lin & Sleigh, Alison & Mada, Marius & Carpenter, Thomas & J. A. Hutchinson, Peter & L. H. Carpenter, Keri. 
Frontiers in Neurology, 2017. 10.3389/fneur.2017.00426. Full article available here.

'Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy'
by Ellie Edlmann, Susan Giorgi-Coll, Peter C Whitfield, Keri LH Carpenter and Peter J Hutchinson.
Journal of Neuroinflammation, 2017. Full article available here.

'Heparin-gold nanoparticles for enhanced microdialysis sampling'
Giorgi-Coll, Susan, Blunt-Foley, Holly, J. A. Hutchinson, Peter & L. H. Carpenter, Keri. 
Analytical and Bioanalytical Chemistry 2017. 10.1007/s00216-017-0447-y. Full article available here.

'Microdialysis monitoring in clinical traumatic brain injury and its role in neuroprotective drug development'
by Eric P Thelin, Keri LH Carpenter, Peter J Hutchinson and Adel Helmy.
The AAPS Journal, 2017. Full article available here.


'Focally perfused succinate potentiates brain metabolism in head injury patients'
by Ibrahim Jalloh, Adel Helmy, Duncan J Howe, Richard J Shannon, Peter Grice, Andrew Mason, Clare N Gallagher, Matthew G Stovell, Susan van der Heide, Michael P Murphy, John D Pickard, David K Menon, T Adrian Carpenter, Peter J Hutchinson and Keri LH Carpenter.
Journal of Cerebral Blood Flow and Metabolism, 2016. Full article available here.

'Extracellular N-Acetylaspartate in Human Traumatic Brain Injury'
by Richard Shannon, Susan van der Heide, Eleanor L. Carter, Ibrahim Jalloh, David K. Menon, Peter J. Hutchinson, and Keri L.H. Carpenter. 
Journal of Neurotrauma, 2016. Full article available here.


Publications 2010-2016