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Cell Culture Modelling of TBI

Mixed_glia_smallMetabolic supplementation of mixed glial cells in culture

A parallel collaborative study with departmental colleagues based in the Anne McLaren Laboratory, Dr Mark Kotter and Joana Tavares (also previously with Dr Ana Amaral) is investigating the effect of metabolic supplementation, such as succinate, on an in vitro cell culture model. This study has shown promising results in the use of succinate to improve cell energy state under both metabolic and inflammatory stress conditions, which corroborated our findings from preliminary human studies.